Midwest tribe Crossword Clue

 The answer to the crossword clue "Midwest tribe" can be OSAGE. It is a 5-letter word that refers to a Native American tribe that originally lived in the Midwestern United States. The Osage were forced to relocate to Oklahoma in the 19th century.

Here are some other Midwest tribes:

Iowa

Kiowa

Missouri

Nebraska

Otoe

Sac

Shawnee

Tonkawa

Wyandot

The exact answer to the crossword clue will depend on the specific puzzle, but Osage is a common answer.