Major inconvenience Crossword Clue

 The most common crossword clue for "major inconvenience" is PAIN. It is a 4-letter word that fits in most crossword puzzles, and it accurately describes the meaning of the word "major inconvenience".

A major inconvenience is something that causes a lot of trouble or difficulty. It can be something that is physical, such as a major traffic jam, or it can be something that is emotional, such as a job loss.

Other possible crossword clues for "major inconvenience" include:

HASSLE

NUISANCE

OBSTACLE

SETBACK

DIFFICULTY

However, these clues are less common than PAIN, and they may not fit into all crossword puzzles.

If you are unsure of the answer to the crossword clue, try to think of words that are 4 letters long and can be used to describe something that causes a lot of trouble or difficulty. You can also try crossing the clue with other clues in the puzzle to get a better idea of the answer.

Here is an example of how the clue "Major inconvenience" might be used in a crossword puzzle:

Clue: Major inconvenience

Answer: PAIN

I hope this helps!