The main impact crossword clue can be effect. Effect is the power or influence that something has on something else. It can be used to describe the physical or emotional impact of something, or the overall outcome of something.
Here are some other possible answers for the main impact crossword clue:
6 letters: RESULT
7 letters: EFFECT
8 letters: CONSEQUENCE
9 letters: IMPACT
10 letters: OUTCOME
I hope this helps!
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